No, but U of L's Total Offense is #19 on schedule-adjusted basis. Louisville has played three teams ranked nationally in the Top 25 on Total Defense.
Cal is #1 averaging 518 yards/game and having played three Top 50 defenses. Contrast that to Baylor which is #1 on offense (720 ypg) without accounting for schedule. But their SOS is 176th nationally; and they have played the 108th, 122nd, 123rd, and 125th rated defenses in the FBS. Their best FBS opponent has been WVU ranked 74th in Total Defense.
All of this stuff has to be weighted against the quality of your schedule. It's how LPT started 5-1 last year and finished 0-6.