I would find it incredible if Bellarmine is favored over Louisville even though I expect the Cards to lose. If Vegas does make Bellarmine the favorite, that would show that UofL has indeed hit rock bottom perception wise.
For Louisville to win the game at home in the yum center and it being considered an upset would definitely be a twilight zone moment.
But I'm afraid Rod Serling will be walking through the front door and the Cards season starts with a huge embarrassment.
Bellarmine 72
Louisville 67